Pharmaceutical Engineering: Optimization of a Pharmaceutical Formulation
نویسندگان
چکیده
The effects of magnesium stearate (MgSt) and shear stress on flow properties and hydrophobicity are not well known. Blends with different concentrations of magnesium stearate and varying amounts of shear were tested using three different procedures: the FT4 Rheometer test, a tap density analyzer, and the Washburn method, to better understand the relation of lubricant concentration, amount of shear, hydrophobicity, and flow properties. The Freeman Technology FT4 Powder Rheometer data showed that the blend with 0.00% MgSt concentration had the poorest flow properties and the 2.00% MgSt blend had the best flow properties. The tap density test revealed no correlation between flow properties and MgSt concentrations or amount of shear, however these results may not be accurate due to limited number of trials. The Washburn method shows that increasing the amount shear stress correlates with an increase in hydrophobicity and vice versa. Similarly, the Washburn method showed a clear correlation between the concentration of MgSt and hydrophobicity.
منابع مشابه
Decision Support Systems for Pharmaceutical Formulation Development Based on Artificial Neural Networks
Once discovered and established as therapeutic agent, the drug substance is used for pharmacotherapy of various diseases. The drug substance itself has unique properties, which in certain cases do not allow for effective therapy. This is the area, where pharmaceutical technology allows to improve drug substance original characteristics by optimization of pharmaceutical formulation. The latter i...
متن کاملA Statistical Approach Towards Development and Optimization of Conventional Immediate Release Tablet of Nimorazole by Wet Granulation Technique
Till date, most of the drugs have been given in conventional immediate release dosage form. Nimorazole is an anticancer drug, used as a hypoxic radiosensitizer in patients undergoing radiotherapy and no formulation has been available in the market till now. Hence, for the purpose to develop an immediate release dosage form, a statistical optimization process has been employed to quantify the ef...
متن کاملSingle Layer Extended Release Two-In-One Guaifenesin Matrix Tablet: Formulation Method, Optimization, Release Kinetics Evaluation and Its Comparison with Mucinex® Using Box-Behnken Design
Guaifenesin, a highly water-soluble active (50 mg/mL), classified as a BCS class I drug.Owing to its poor flowability and compressibility, formulating tablets especially high-dose one,may be a challenge. Direct compression may not be feasible. Bilayer tablet technology appliedto Mucinex®, endures challenges to deliver a robust formulation. To overcome challengesinvolved in bilayer-tablet manufa...
متن کاملSingle Layer Extended Release Two-In-One Guaifenesin Matrix Tablet: Formulation Method, Optimization, Release Kinetics Evaluation and Its Comparison with Mucinex® Using Box-Behnken Design
Guaifenesin, a highly water-soluble active (50 mg/mL), classified as a BCS class I drug.Owing to its poor flowability and compressibility, formulating tablets especially high-dose one,may be a challenge. Direct compression may not be feasible. Bilayer tablet technology appliedto Mucinex®, endures challenges to deliver a robust formulation. To overcome challengesinvolved in bilayer-tablet manufa...
متن کاملFormulation Optimization and Assessment of Dexamethasone Orally Disintegrating Tablets Using Box-Behnken Design
The aim of this study was to prepare orally disintegrating tablets (ODTs) containingdexamethasone (DEX) by direct compression method with sufficient hardness and rapiddisintegration time. In order to save time, money, and human resources in designing andimprovement of formulation, the statistical software Design Expert is used. Box–Behnkenresponse surface methodology was applied to evaluate and...
متن کاملFormulation Optimization and Assessment of Dexamethasone Orally Disintegrating Tablets Using Box-Behnken Design
The aim of this study was to prepare orally disintegrating tablets (ODTs) containingdexamethasone (DEX) by direct compression method with sufficient hardness and rapiddisintegration time. In order to save time, money, and human resources in designing andimprovement of formulation, the statistical software Design Expert is used. Box–Behnkenresponse surface methodology was applied to evaluate and...
متن کامل